Dog hereditary diseases
Dog hereditary diseases
Certain dog breeds are more susceptible to medication than others. For example, collies, Whippets, Australian Shepherds, White Swiss Shepherds and some other breeds are more sensitive to antiparasitic and anticancer drugs. This is due to a mutation in the drug susceptibility gene (MDR1). The product of the MDR1 gene, P-glycoprotein, is a component of the blood-brain barrier. If it is damaged, various substances may penetrate into the dog's brain and not be removed. In this case, some medications can be especially dangerous.
In addition to influencing the penetration of drugs into the brain, P-glycoprotein functions in the gastrointestinal tract, liver and kidneys of the dog. These organs, normally, are involved in the decay and excretion of drugs. Therefore, in dogs with MDR1 deficiency, the pharmacokinetic properties of a number of drugs change, which leads to an increase in their bioavailability (that is, the drug is absorbed more easily than it is intended, which means that the body needs significantly lower doses) and / or a decrease in the excretion of substances by the liver, kidneys and intestines. Thus, in dogs with MDR1 deficiency, plasma drug concentrations increase and an adverse drug reaction may occur.
When a dog with MDR1 deficiency is exposed to a number of drugs, the following symptoms may occur: excessive salivation, ataxia, blindness, tremors, depression, coma; death is possible in some cases.
Dogs with MDR1 deficiency do not have any external manifestations of any disturbances, sensitivity to drugs is detected only with direct exposure to appropriate medications. Unfortunately, it can be quite difficult to prevent the consequences of using drugs, in some cases hospitalization may even be required.
Since the disease is of a genetic nature, a DNA test has been developed that is available for different breeds of dogs to identify dogs with MDR1 deficiency, as well as genetic carriers. Genetic testing is based on the application of the latest molecular genetic knowledge and technology. It allows you to distinguish with 100% certainty a healthy dog from a clinically normal dog who is a carrier, and from a dog with a hypersensitivity to medication. Testing can be done at any age, for both puppies and adult dogs. Knowing the test results will help avoid side effects when using a number of drugs. When testing, a mutation in DNA is analyzed, leading to the development of MDR1 deficiency. The test detects a defective (mutant) copy of the gene and a normal copy of the gene.
Drugs with a proven negative effect on the nervous system of dogs with a mutation in the MDR1 gene - the use of these drugs is possible only under medical supervision and in lower dosages.
The list of commercial drugs could be longer! Pay attention to the active ingredient!
Drug groups are highlighted in red, categorically prohibited for use in dogs of genotype MM (two copies mutant gene).
Orange indicates groups of drugs, the use of which in dogs of the genotype MM not desirable, in dogs of genotype NM should be carried out under medical supervision.
To select a group of drugs, click on the three strips below and choose required from the dropdown list:
Active ingredient Some commercial drugs Ivermectin Ivermek, Diapek, Ecomectin, Equimax, Eqvalan, Ivomek, Noromectin, Paramectin, Qualimec, Sumex, Virbamek Doramectin Dectomax Moxidectin Cydectin, Nedectin, Equest Metronidazole Flagil Emodepsid Profender Milbemycin Selamectin
Active ingredient Some commercial drugs Vinca alkaloids Vinblastine, Vincristine, Vindesine, Vinorelbine, Doxirubicin Doxorubicin Adriblastin, Doxolek, Doxolem, Kelix, Rastocin, Sindroxocin Paclitaxel Abitaxel, Abraksan, Intaxel, Kanataxen, Mitotax, Paklitera, Paxen, Paktalek, Sindaxel, Taksakad, Taxol, Yutaxan Docetaxel Docetera, Novotax, Oncodocel, Taxotere, Tautax Methotrexate Zexat, Methodject, Trexan, Evetrex Etoposide Lastet, Vepesid, Phytozide Mitoxantrone Oncotron, Novantron, Mitolek
Active ingredient Some commercial drugs Dexamethasone Decadron, Dexaven, Dexazone, Dexamed, Dexamethasonlong, Dexapos, Dexafar, Dexon, Dexoftan, Maxidex, Megadexan, Ozurdex, Oftan, Fortecortin
Active ingredient Some commercial drugs Cyclosporine Consupren, Orgasporin, Panimun Bioral, Restasis, Sandimmun, Cycloral, Ecoral Tacrolimus Advagraf, Prograf, Protopic, Takrosel
Active ingredient Some commercial drugs Digoxin Novodigal Methyldigoxin Bemecor, Lanitop, Medilazid
Active ingredient Some commercial drugs Verapamil Veracard, Verogalid, Isoptin, Kaveril, Lekoptin, Finoptin Diltiazem Altiazem, Blokaltsin, Diakordin, Dilcardia, Diltazem, Dilren, Dilcem, Silden, Cardil, Cortiazem, Tiakem Quinidine Quinidin
Active ingredient Some commercial drugs Morphine M-Eslon, MST Continus, Scanan Butorphenol Moradol, Stadol
Active ingredient Some commercial drugs Metoclopramide Cerucal, Raglan, Ceruglan, Perinorm, Metamol, Apo-Metoclop Ondansetron Zofran, Latran, Sturgeon, Emeset, Emetron, Lazaran, Setronon, Domegan, Ondantor, Ondasol Domperidone Motilium, Motilak, Passages, Motonium, Motinorm, Damelium, Motiject, Domet, Domstal
Active ingredient Some commercial drugs Sparfloxacin Sparflo Grepafloxacin Raksar Erythromycin Grunamycin, Ermidse, Ilozon, Erifluid Rifampicin R-cin, Rifadin, Eremfat, Benemycin, Rimpin, Makox, Rifamor, Rimpacin, Rimactan, Rifaren
Active ingredient Some commercial drugs Ebastine Kestin
Active ingredient Some commercial drugs Acepromazine Vetranquil
Active ingredient Some commercial drugs Loperamide Imodium, Diara, Laremid, Lopedium, Suprilop, Enterobene
Autosomal recessive inheritanceARMM - sickNM - healthy, carrierNN is healthy
- Afghan Hound
- Australian cattle dog
- Australian shepherd
- Border Collie
- Cane corso
- Chesapeake bay retriever
- Collie rough
- Collie smooth-haired
- Dachshund miniature long-haired
- Dachshund miniature smooth-haired
- Dachshund miniature wire-haired
- Dachshund rabbit long-haired
- Dachshund rabbit smooth-haired
- Dachshund rabbit wire-haired
- Dachshund standard
- Dachshund standard long-haired
- Dachshund standard wire-haired
- Dogue de bordeaux
- East european shepherd
- English shepherd
- French bulldog
- German shepherd
- Labrador retriever
- Miniature american shepherd
- Miniature australian shepherd
- Neapolitan mastiff
- Old english bulldog
- Old English Shepherd Dog (Bobtail)
- Silky windhund
- White swiss shepherd